Parkinson’s is a disease that affects the nervous system, particularly the area of the brain that controls balance and movement (substantia nigra). Nerve cells in the substantia nigra are responsible for making the chemical messenger dopamine, used by nerve cells to convey messages. Progressive destruction of nerve cells lead to a reduction in dopamine, which results in the characteristic trembling and shaking of Parkinson’s.
Parkinson’s disease is estimated to affect approximately 1% of individuals over 60 years of age. The late-onset form of Parkinson’s refers to individuals who show symptoms after 50 years of age, while cases that begin before the age of 50 are classified as early-onset disease. Only about 4% of Parkinson’s cases are the early-onset form of the disease.
Take this test to find out if you are at increased risk of developing late-onset Parkinson’s disease.
Around 15% of individuals with Parkinson’s disease have a family history indicating that there are genetic changes that increase the risk of disease.
This test detects two genetic variants in the LRRK2 and GBA genes associated with an increased risk of late-onset Parkinson’s disease in individuals of European, Ashkenazi Jewish and North African Berber descent.
Both variants are inherited in an autosomal dominant manner, meaning that just one copy of a variant is associated with an increased risk of disease. However, not everyone who inherits these variants will develop the disease.
Symptoms of Parkinson’s Disease
- Tremors (trembling or shaking) of limbs usually affecting one side of the body
- Muscle stiffness and rigidity
- Slowing movement (bradykinesia)
- Movement difficulties (akinesia)
- Impaired balance and coordination
How It Works
Step 1: Sign up for a free DNA Access account.
Step 2: Upload your DNA markers to DNA Access.
Step 3: Log in to your account to access your results when they are ready.