Celiac Disease (2 SNP) DNA Test

Almost all people with celiac disease carry at least one genetic risk allele. Find out your risk.

  • This is a SNP test for two HLA variants associated with an increased risk of celiac disease
  • Detect the celiac disease-associated HLA haplotypes (HLA-DQ2.5 and HLA-DQ8)
  • Are you at increased risk of celiac disease?

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Detailed Description

Celiac disease is an autoimmune disease in response to the digestion of gluten, a protein found in wheat, barley, rye and other grains, and is commonly included in many processed and packaged foods.

Each time an affected individual ingests gluten, their immune system reacts aberrantly and damages the lining of their small intestine. This intestinal damage inhibits the absorption of vitamins, minerals and nutrients, leading to a wide range of disease signs and symptoms.

The test only looks at two HLA SNPs associated with celiac disease. You can upgrade to a DNA sequencing test that detects a more complete array of celiac disease-associated genetic variants with the DNA Celiac Disease Test. 

The Genetics

Variation in a genetic grouping known as the HLA complex is associated with an increased risk of celiac disease. The HLA complex is important for the immune system to distinguish between the body’s own proteins and proteins from foreign invaders (e.g. viruses and bacteria).

The HLA-DQA1 gene is normally inherited together with a neighbouring gene known as HLA-DQB1. This is known as an HLA haplotype. Approximately 95% of celiac-affected individuals carry one or more of the celiac disease-associated HLA haplotypes (HLA-DQ2.5 and HLA-DQ8). However, only a subset of people carrying these haplotypes develop celiac disease, so this genetic test must be used in combination with other analyses (symptoms and blood IgA levels). 

Symptoms Associated with Celiac Disease 

  • Flatulence
  • Bloating
  • Constipation and/or diarrhea
  • Appetite changes
  • Pale or bloody stools
  • Nausea and vomiting

How It Works

Step 1: Sign up for a free DNA Access account.
Step 2: Upload your DNA markers to DNA Access.
Step 3: Log in to your account to access your results when they are ready.