Cancer is a disease characterized by an uncontrolled growth of abnormal cells. It is caused by DNA changes that affect the normal function of cellular proteins, leading to an accumulation of abnormal cells.
This DNA test detects genetic changes in the BRCA1 and BRCA2 genes. These two genes provide instructions for the BRCA1 and BRCA2 proteins involved in the repair of damaged DNA. People who produce non-functional BRCA1 and BRCA2 proteins have an increased risk of cancer.
Take this test to find out if you have inherited a BRCA1 or BRCA2 variant and are at increased risk of developing cancer.
More than 1000 genetic variants in the BRCA1 and BRCA2 genes have been linked to increased cancer risk. The cancer types most strongly associated with these variants are breast cancer in both genders, and ovarian cancer.
BRCA1 and BRCA2 variants may also increase the risk of prostate cancer, pancreatic cancer, and melanoma.
In females, the inheritance of a BRCA1 or BRCA2 "cancer risk" variant is associated with:
- 45-85% increased risk of breast cancer by 70 years
- Increased risk of early-onset breast cancer (before 45 years)
- Increased risk of suffering from multiple breast cancers
- Possible increased risk of pancreatic cancer (for BRCA1 or BRCA2), and melanoma (for BRCA2 only)
- Increased risk of ovarian cancer (39-46% chance for BRCA1 and 10-27% chance for BRCA2)
In males, the inheritance of a BRCA1 or BRCA2 "cancer risk" variant is associated with an increased risk of breast cancer, and a possible increased risk of prostate cancer, pancreatic cancer, and melanoma.
This test detects two genetic variants in the BRCA1 gene and one genetic variant in the BRCA2 gene.
- rs386833395 (185delAG)
- rs80357906 (5382insC)
- rs80359550 (6174delT)
These variants are most common in people of Ashkenazi Jewish descent.
- Family and personal history of cancer
- Dense breasts
- Reproductive history
- Alcohol consumption
- Hormone exposure
- Lack of physical exercise
- Exposure to ionizing radiation
How It Works
Step 1: Sign up for a free DNA Access account.
Step 2: Upload your DNA markers to DNA Access.
Step 3: Log in to your account to access your results when they are ready.